Purchase Metaxalone (Skelaxin) 400 mg pills online


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Indications and usage:

Skelaxin (Metaxalone) is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.


Dosage and administration:

The recommended dose for adults and children over 12 years of age is one 800 mg tablet three to four times a day.


Dosage forms and strengths:

Skelaxin (Metaxalone) brand is available as an 400 mg and 800 mg oval, scored pink tablet inscribed with 8667 on the scored side and "S" on the other.


Overdosage:

Deaths by deliberate or accidental overdose have occurred with metaxalone, particularly in combination with antidepressants, and have been reported with this class of drug in combination with alcohol.

Serotonin syndrome has been reported when Skelaxin was used at doses higher than the recommended dose.

When determining the LD50 in rats and mice, progressive sedation, hypnosis, and finally respiratory failure were noted as the dosage increased. In dogs, no LD50 could be determined as the higher doses produced an emetic action in 15 to 30 minutes.

Treatment

Gastric lavage and supportive therapy. Consultation with a regional poison control center is recommended.


Contraindications:

  • Known hypersensitivity to any components of Skelaxin tablets.
  • Known tendency to drug induced, hemolytic, or other anemias.
  • Significantly impaired renal or hepatic function.


    Warnings:

    Serotonin syndrome

    Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of serotonergic drugs with Skelaxin used within the recommended dosage range and with metaxalone as a single agent taken at doses higher than the recommended dose. Serotonergic drugs include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, opioids (particularly fentanyl, meperidine, and methadone), drugs that affect the serotonergic neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), and drugs that impair metabolism of serotonin (including monoamine oxidase (MAO) inhibitors, both those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).

    Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination, rigidity), and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). The onset of symptoms generally occurs within several hours to a few days, but may occur later than that. Discontinue Metaxalone (Skelaxin) if serotonin syndrome is suspected.

    Risks from concomitant use with alcohol or other CNS depressants

    The sedative effects of Skelaxin and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants (TCAs)) may be additive. Exercise caution with patients who take more than one of these CNS depressants simultaneously. Follow patients closely for signs and symptoms of respiratory depression and sedation.


    Precautions:

  • Metaxalone should be administered with great care to patients with pre-existing liver damage. Serial liver function studies should be performed in these patients.
  • False-positive Benedict's tests, due to an unknown reducing substance, have been noted. A glucose-specific test will differentiate findings.
  • Taking Skelaxin with food may enhance general CNS depression; elderly patients may be especially susceptible to this CNS effect.


    Side effects, adverse reactions:

    The most common adverse reactions of metaxalone include:

  • CNS: drowsiness, dizziness, headache, nervousness, irritability.
  • Digestive: nausea, vomiting, gastrointestinal upset.

    Other adverse reactions are:

  • Immune system: anaphylaxis, hypersensitivity reaction, rash with or without pruritus.
  • Hematologic: leukopenia, hemolytic anemia.
  • Hepatobiliary: jaundice.
  • CNS: cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of serotonergic drugs with Skelaxin used within the recommended dosage range and with metaxalone as a single agent taken at doses higher than the recommended dose.

    To report suspected adverse reactions of Metaxalone (Skelaxin) pills, contact Pfizer pharmaceutical company or your local FDA.


    Drug interactions:

    CNS depressants

    The sedative effects of Skelaxin and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants (TCAs)) may be additive. Exercise caution with patients who take more than one of these CNS depressants simultaneously. Follow patients closely for signs and symptoms of respiratory depression and sedation.

    Serotonergic drugs

    Serotonin syndrome has resulted from concomitant use of serotonergic drugs with metaxalone used within the recommended dosage range. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Discontinue Skelaxin (Metaxalone) if serotonin syndrome is suspected.

    Examples of serotonergic drugs include: selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, opioids (particularly fentanyl, meperidine, and methadone), drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).

    Related medications:

  • Modafinil (Modalert)
  • Tramadol (Ultram)


    Use in specific populations:

    Pregnancy

    Reproduction studies in rats have not revealed evidence of impaired fertility or harm to the fetus due to metaxalone. Post marketing experience has not revealed evidence of fetal injury, but such experience cannot exclude the possibility of infrequent or subtle damage to the human fetus. Safe use of metaxalone has not been established with regard to possible adverse effects upon fetal development. Therefore, metaxalone tablets should not be used in women who are or may become pregnant and particularly during early pregnancy unless, in the judgement of the physician, the potential benefits outweigh the possible hazards.

    Nursing mothers

    It is not known whether this drug is secreted in human milk. As a general rule, nursing should not be undertaken while a patient is on a drug since many drugs are excreted in human milk.

    Pediatric use

    Safety and effectiveness in children 12 years of age and below have not been established.


    Information for patients:

    Driving or operating heavy machinery

    Skelaxin may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle, especially when used with alcohol or other CNS depressants.

    Serotonin syndrome

    Inform patients that Skelaxin could cause a rare but potentially life-threatening condition resulting from administration of doses higher than the recommended dose or from concomitant administration of serotonergic drugs with Metaxalone used within the recommended dosage range. Warn patients of the symptoms of serotonin syndrome and to seek medical attention right away if symptoms develop. Instruct patients to inform their healthcare providers if they are taking, or plan to take, serotonergic medications.


    Here is a list of popular medications containing metaxalone as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Flexura
  • Tablets, Modified Release; Oral; Metaxalone 400 mg
  • Tablets; Oral; Metaxalone 400 mg
  • Sun Pharmaceutical Industries
  • Metaxalone
  • Tablets; Oral; Metaxalone 800 mg
  • Sandoz
  • Skelaxin
  • Tablets; Oral; Metaxalone 400 mg
  • Tablets; Oral; Metaxalone 800 mg
  • Pfizer
  • Blenheim Pharmacal
  • Cardinal Health
  • CorePharma
  • Jones Pharma
  • King Pharmaceuticals
  • Mallinckrodt